An efficient one-pot, regio- and stereoselective synthesis of novel pentacyclic-fused pyrano[3,2,c]chromenone or quinolinone benzosultone derivatives in water

作者：Ghandi Mehdi^*; Nazeri Mohammad Taghi; Kubicki Maciej

来源：Tetrahedron, 2013, 69(24): 4979-4989.

DOI：10.1016/j.tet.2013.04.018

• Knoevenagel hetero-Diels-Alder
• Fused pyranochromenone
• Benzosultones

A one-pot strategy has been developed for the synthesis of novel pentacyclic-fused pyranochromenone and pyranoquinolinone benzosultone derivatives. The in situ generated 2-formylphenyl-(E)-2-phenylethenesulfonates, from condensation of 2-hydroxybenzaldehydes with (E)-2-phenylethenesulfonyl chloride, underwent reaction with 4-hydroxycoumarins or 4-hydroxyquinolinone in water, affording the desired products in moderate to excellent yields. These reactions presumably proceed through O-sulfonylation/Knoevenagel condensation/hetero-Diels-Alder reaction cascade.

• 出版日期2013-6-17