Vitamin D deficiency associates with gamma-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis

作者：Barker Tyler^*; Henriksen Vanessa T; Rogers Victoria E; Aguirre Dale; Trawick Roy H; Rasmussen G Lynn; Momberger Nathan G

来源：Redox Biology, 2014, 2: 466-474.

DOI：10.1016/j.redox.2014.01.024

• Vitamin D
• Cytokines
• Muscle strength
• Vitamin E

Knee osteoarthritis (OA) is a degenerative joint condition and a leading cause of physical disability in the United States. Quadriceps weakness and inflammatory cytokines contribute to the pathogenesis of knee OA, and both of which, increase with vitamin D deficiency. Other micronutrients, such as vitamins C and E and beta-carotene, modulate inflammatory cytokines and decrease during inflammation. The purpose of this study was to test the hypothesis that vitamin D deficiency associates with quadriceps weakness, an increase in serum cytokines, and a decrease in circulating micronutrients in subjects with knee OA. Subjects (age, 48 +/- 1 y; serum 25(OH)D, 25.8 +/- 1.1 ng/mL) with knee OA were categorized as vitamin D deficient (n=17; serum 25(OH)D <= 20 ng/mL), insufficient (n=21; serum 25(OH)D 20-29 ng/mL), or sufficient (n=18; serum 25(OH)D >= 30 ng/mL). Single-leg strength (concentric knee extension-flexion contraction cycles at 60 degrees/s) and blood cytokine, carotene (alpha and beta), ascorbic acid, and tocopherol (alpha and gamma) concentrations were measured. Quadriceps peak torque, average power, total work, and deceleration were significantly (all p < 0.05) impaired with vitamin D deficiency. Serum gamma-tocopherol concentrations were significantly (p < 0.05) increased with vitamin D deficiency. In the vitamin D sufficient group, gamma-tocopherol inversely correlated (r=-0.47, p < 0.05) with TNF-alpha, suggesting a pro-inflammatory increase with a gamma-tocopherol decrease despite a sufficient serum 25(OH)D concentration. We conclude that vitamin D deficiency is detrimental to quadriceps function, and in subjects with vitamin D sufficiency, gamma-tocopherol could have an important anti-inflammatory role in a pathophysiological condition mediated by inflammation.

• 出版日期2014