Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers

作者：de Gonzalo Calvo David; Neitzert Kim; Fernandez Maria; Vega Naredo Ignacio; Caballero Beatriz; Garcia Macia Marina; Manuel Suarez Francisco; Josefa Rodriguez Colunga Maria; Jose Solano Juan; Coto Montes Ana^*

来源：Free Radical Biology and Medicine, 2010, 49(5): 733-737.

DOI：10.1016/j.freeradbiomed.2010.05.019

• Aging
• Low oxygen saturation
• Hypoxia
• Oxidative stress
• Protein damage
• Total antioxidant activity
• TNF-alpha
• IL-6
• Free radicals

Oxidative stress has been reported to increase during aging and conditions of hypoxia Although low oxygen saturation has a key role in the development of several age-related diseases, the underlying mechanisms are still unknown We analyzed the relationship between aging and hypoxia by examining oxidative stress and inflammation-related cytokines. We collected blood samples from three volunteer experimental groups, consisting of one group of normoxic middle-aged people and two groups of individuals older than 75 years, which comprised a subgroup of normoxic subjects and another with oxyhemoglobin saturation lower than 95% (hypoxic) Our results showed a fall in antioxidant defenses in older people with hypoxia TNT-a, the first element in the cytokine cascade, was significantly increased in the aged population, implying that aging is accompanied by a gradual increase in this inflammatory biomarker. IL-6 was not associated with aging, but it was highly elevated under hypoxia conditions in elderly subjects Thus, these parameters could be used as biological markets of different inflammatory processes triggered by oxidative stress induced by a decrease in antioxidant def

• 出版日期2010-9-1