Maternal Urinary Bisphenol A during Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study

作者：Chevrier Jonathan^*; Gunier Robert B; Bradman Asa; Holland Nina T; Calafat Antonia M; Eskenazi Brenda; Harley Kim G

来源：Environmental Health Perspectives, 2013, 121(1): 138-144.

DOI：10.1289/ehp.1205092

• bisphenol A
• endocrine disruption
• neonates
• pregnancy
• thyroid hormone

BACKGROUND: Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain development, no studies have investigated relations between BPA exposure and thyroid function in pregnant women or neonates.
OBJECTIVE: Our goal was to evaluate whether exposure to BPA during pregnancy is related to thyroid hormone levels in pregnant women and neonates.
METHODS: We measured BPA concentration in urine samples collected during the first and second half of pregnancy in 476 women participating in the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) study. We also measured free thyroxine (T-4), total T-4, and thyroid-stimulating hormone (TSH) in women during pregnancy, and TSH in neonates.
RESULTS: Associations between the average of the two BPA measurements and maternal thyroid hormone levels were not statistically significant. Of the two BPA measurements, only the one taken closest in time to the TH measurement was significantly associated with a reduction in total T-4 (beta = -0.13 mu g/dL per log(2) unit; 95% CI: -0.25, 0.00). The average of the maternal BPA concentrations was associated with reduced TSH in boys (-9.9% per log(2) unit; 95% CI: -15.9%, -3.5%) but not in girls. Among boys, the relation was stronger when BPA was measured in the third trimester of pregnancy and decreased with time between BPA and TH measurements.
CONCLUSION: Results suggest that exposure to BPA during pregnancy is related to reduced total T-4 in pregnant women and decreased TSH in male neonates. Findings may have implications for fetal and neonatal development.

• 出版日期2013-1