Sex and Catheter Ablation for Ventricular Tachycardia An International Ventricular Tachycardia Ablation Center Collaborative Group Study

作者：Frankel David S^*; Tung Roderick; Santangeli Pasquale; Tzou Wendy S; Vaseghi Marmar; Di Biase Luigi; Nagashima Koichi; Tedrow Usha; Bunch T Jared; Tholakanahalli Venkatakrishna N; Dendi Raghuveer; Reddy Madhu; Lakkireddy Dhanunjaya; Dickfeld Timm; Weiss J Peter; Mathuria Nilesh; Vergara Pasquale; Patel Mehul; Nakahara Shiro; Vakil Kairav; Sauer William H; Callans David J; Natale Andrea; Stevenson William G; Della Bella Paolo; Shivkumar Kalyanam

来源：JAMA Cardiology, 2016, 1(8): 938-944.

DOI：10.1001/jamacardio.2016.2361

IMPORTANCE Significant differences have been described between women and men regarding presentation, mechanism, and treatment outcome of certain arrhythmias. Previous studies of ventricular tachycardia (VT) ablation have not included sufficient women for meaningful comparison.
OBJECTIVE To compare outcomes between women and men with structural heart disease undergoing VT ablation.
DESIGN, SETTING, AND PARTICIPANTS Investigator-initiated, multicenter, observational study performed between 2002 and 2013, conducted by the International VT Ablation Center Collaborative Group, consisting of 12 high-volume ablation centers. Consecutive patients with structural heart disease undergoing VT ablation were studied. Structural heart disease was defined as left ventricular ejection fraction less than 55%, hypertrophic cardiomyopathy, or right ventricular cardiomyopathy, with scar confirmed during electroanatomic mapping.
EXPOSURES Catheter ablation.
MAIN OUTCOMES AND MEASURES Ventricular tachycardia-free survival and transplant-free survival were compared between women and men. Cox proportional hazard modeling was performed.
RESULTS Of 2062 patients undergoing ablation, 266 (12.9%) were women. Mean (SD) age was 62.4 (13.3) years and 1095 (53.1%) had ischemic cardiomyopathy. Compared with men, women were younger, with higher left ventricular ejection fraction and less VT storm. Despite this, women had higher rates of 1-year VT recurrence following ablation (30.5% vs 25.3%; P=.03). This difference was only partially explained by higher prevalence of nonischemic cardiomyopathy among women and was actually most pronounced among those with ischemic cardiomyopathy.
CONCLUSIONS AND RELEVANCE In 12 high-volume ablation centers, women with structural heart disease have worse VT-free survival following ablation than men. Whether this is owing to differences in referral pattern, arrhythmia substrate, or undertreatment requires further study.

• 出版日期2016-11