Assessment of Parkinson%26apos;s disease risk loci in Greece

作者：Kara Eleanna; Xiromerisiou Georgia; Spanaki Cleanthe; Bozi Maria; Koutsis Georgios; Panas Marios; Dardiotis Efthimios; Ralli Styliani; Bras Jose; Letson Christopher; Edsall Connor; Pliner Hannah; Arepalli Sampath; Kalinderi Kallirhoe; Fidani Liana; Bostantjopoulou Sevasti; Keller Margaux F; Wood Nicholas W; Hardy John; Houlden Henry; Stefanis Leonidas; Plaitakis Andreas; Hernandez Dena; Hadjigeorgiou Georgios M; Nalls Mike A; Singleton Andrew B^*

来源：Neurobiology of Aging, 2014, 35(2): 442. e9.

DOI：10.1016/j.neurobiolaging.2013.07.011

• Parkinson%26apos
• s disease
• GWAS
• GCTA
• Genetics
• Greece
• Risk profiles

Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson%26apos;s disease (PD) have been successful in identifying numerous risk variants pointing to novel pathways potentially implicated in the pathogenesis of PD. Contributing to these GWAS efforts, we performed genotyping of previously identified risk alleles in PD patients and control subjects from Greece. We showed that previously published risk profiles for Northern European and American populations are also applicable to the Greek population. In addition, although our study was largely underpowered to detect individual associations, we replicated 5 of 32 previously published risk variants with nominal p values %26lt;0.05. Genome-wide complex trait analysis revealed that known risk loci explain disease risk in 1.27% of Greek PD patients. Collectively, these results indicate that there is likely a substantial genetic component to PD in Greece, similarly to other worldwide populations, that remains to be discovered. Published by Elsevier Inc.

• 出版日期2014-2
• 单位NIH