A facile construction of gradient micro-patterned OCP coatings on medical titanium for high throughput evaluation of biocompatibility

作者：Song, Ran; Liang, Jianhe; Lin, Longxiang; Zhang, Yanmei; Yang, Yun; Lin, Changjian^*

来源：Journal of Materials Chemistry B, 2016, 4(22): 4017-4024.

DOI：10.1039/c6tb00458j

• DIRECTING CELL-MIGRATION
• OCTACALCIUM-PHOSPHATE
• SOLAR-CELLS
• STEM-CELLS
• IN-VITRO
• POLYMER BRUSHES
• TIO2 FILM
• FABRICATION
• SURFACES
• CONTACT

Base on a superhydrophobic-superhydrophilic micro-patterned template, a facile construction of gradient micro-patterned octacalcium phosphate (OCP) coatings on titanium has been firstly developed for high-throughput evaluation of biocompatibility. The gradient OCP coatings with tunable crystal morphologies involving scattered-flower-like, scattered-flower-ribbon-like, short-ribbon-like and long-ribbon-like were fabricated in different micro-units on the same surface. The significant difference of mineralization behavior of the gradient OCP coatings in the micro-patterns was observed visually and efficiently. In vitro cultures of MC3T3-E1 cells showed that the number and morphology of cells selectively adhered on the micro-units of gradient structure of OCP coatings were distinctly different, indicating that the cells are sensitive to the different structures of OCP coatings on medical titanium. The gradient micro-patterned construction is potentially a powerful method for not only high-throughput screening of the biocompatibility of various biomaterials, but also efficient development of advanced biomaterials by controlling cell immobilization and inducing cell response.

• 出版日期2016
• 单位厦门大学