Modulation of Respiratory Function by 5,10,15,20-Tetrakis(N-methyl-4-pyridyl)Porphyrin-Zn(II) Tetrachloride in Isolated Rat Liver Mitochondria

作者：Kerti Viorica; Coricovac Dorina; Duicu Oana; Danila Maria; Dehelean Cristina; Fagadar Cosma Eugenia; Muntean Danina^*; Noveanu Lavinia

来源：Revista de Chimie, 2014, 65(4): 447-449.

• Zn-metalloporphyrin
• rat liver mitochondria
• respiratory parameters
• uncoupling

Mitochondria plays the central role in several degenerative and hyperproliferative pathologies and characterization of compounds able to enter mitochondria represents a highly targeted field for drug development. In the present paper we investigated the effects of a water-soluble porphyrin, 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin-Zn(II)-tetrachloride (Zn-TNMPyP) on parameters of respiratory function in isolated rat liver mitochondria. Our data show that Zn-TNMPyP acts as a potent uncoupler of mitochondria with potential therapeutic effect.

• 出版日期2014-4