Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

作者：Bianco Suzy D C; Peng Ji Bin; Takanaga Hitomi; Suzuki Yoshiro; Crescenzi Alessandra; Kos Claudine H; Zhuang Liyan; Freeman Michael R; Gouveia Cecilia H A; Wu Jiangping; Luo Hongyu; Mauro Theodora; Brown Edward M; Hediger Matthias A^*

来源：Journal of Bone and Mineral Research, 2007, 22(2): 274-285.

DOI：10.1359/JBMR.061110

• intestinal calcium absorption
• renal excretion
• TRPV6
• alopecia
• vitamin D

We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis, including defective intestinal Ca2+ absorption, increased urinary Ca2+ excretion, decreased BMD, deficient weight gain, and reduced fertility. Although our Trpv6 KO affects the closely adjacent EphB6 gene, the phenotype reported here is not related to EphB6 dysfunction.

• 出版日期2007-2