New Helical Folds in alpha-Peptides with Alternating Chirality

作者：Sharma Gangavaram V M^*; Venkateshwarlu Gajulapati; Reddy Pothula Purushotham; Kunwar Ajit C

来源：Chemistry - A European Journal, 2014, 20(36): 11428-11438.

DOI：10.1002/chem.201403164

• chirality
• helical induction
• helical structures
• hybrid structures
• peptides

In alpha-peptides, the 8/10 helix is theoretically predicted to be energetically unstable and has not been experimentally observed so far. Based on our earlier studies on 'helical induction' and 'hybrid helices', we have adopted the 'end-capping' strategy to induce the 8/10 helix in alpha-peptides by using short alpha/beta-peptides. Thus, alpha-peptides containing a regular string of alpha-amino acids with alternating chirality were end capped by alpha/beta-peptides with 11/9-helical motifs at the termini. Extensive NMR spectroscopy studies of these peptides revealed the presence of a hitherto unknown 8/10-helical pattern; the H-bonds in the shorter pseudorings were rather weak. The approach of using short helical motifs to induce new mixed helices in alpha-peptides could provide avenues for more versatile design strategies.

• 出版日期2014-9-1