Does APOE Genotype Modify the Relations Between Serum Lipid and Erythrocyte Omega-3 Fatty Acid Levels?

作者：Harris William S^*; Pottala James V; Thiselton Dawn L; Varvel Stephen A; Baedke Alison M; Dayspring Thomas D; Warnick G Russell; McConnell Joseph P

来源：Journal of Cardiovascular Translational Research, 2014, 7(5): 526-532.

DOI：10.1007/s12265-014-9554-8

• APOE genotype
• APOE4
• Omega-3 fatty acids
• Lipids
• Low-density lipoproteins
• Triglycerides
• apoB

Earlier reports indicated that patients with the apolipoprotein APOE epsilon 4 allele responded to fish oil supplementation with a rise in serum low-density lipoprotein cholesterol (LDL-C) compared to epsilon 3 homozygotes. In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Data from 136,701 patients were available to compare lipid biomarker levels across Omega-3 Index categories associated with heart disease risk in all APOE genotypes. We found no adverse interactions between APOE genotype and the Omega-3 Index for LDL-C, LDL particle number, apoB, HDL-C, or triglycerides. However, we did find evidence that epsilon 2 homozygotes lack an association between omega-3 status and LDL-C, apoB, and LDL particle number. In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.

• 出版日期2014-7