Anti-Vibrio Indole-Diterpenoids and C-25 Epimeric Steroids From the Marine-Derived Fungus Penicillium janthinellum

作者：Guo, Xing-Chen; Xu, Lan-Lan; Yang, Rui-Yun; Yang, Meng-Yue; Hu, Lian-Dong; Zhu, Hua-Jie^*; Cao, Fei^*

来源：Frontiers in Chemistry, 2019, 7: 80.

DOI：10.3389/fchem.2019.00080

• Penicillium janthinellum
• indole-diterpenoid
• steroid
• absolute configuration
• anti-Vibrio activity

A systematic chemical exploration of the marine-derived fungus Penicillium janthinellum led to the isolation of four indole-diterpenoid derivatives (1-4), including new penijanthines C and D (1 and 2), and a pair of new steroidal epimers, penijanthoids A and B (5 and 6). The calculated ECD spectra and Snatzke's method for the new compound 1 were carried out to determine its absolute configuration. The absolute configuration of 3 was established by X-ray diffraction and calculated ECD methods for the first time. DP4plus approach was used to elucidate the absolute configurations of the C-25 epimeric steroids 5 and 6. 25-Epimeric 5 and 6 represent the first examples of steroids forming a five-membered lactone between C-23 and C-27 from marine fungi. Compounds 1, 2, 5, and 6 displayed significant anti-Vibrio activity (Minimum inhibitory concentration, MIC values ranging from 3.1 to 50.0 mu M) against three pathogenic Vibrio spp.

• 出版日期2019-2-15
• 单位河北大学; 广西师范大学