Assessment of changes in vascularity and blood volume in canine sarcomas and squamous cell carcinomas during fractionated radiation therapy using quantified contrast-enhanced power Doppler ultrasonography A preliminary study

作者：Ohlerth Stefanie^*; Bley Carla Rohrer; Laluhova Dagmar; Roos Malgorzata; Kaser Hotz Barbara

来源：Veterinary Journal, 2010, 186(1): 58-63.

DOI：10.1016/j.tvjl.2009.07.006

• Power
• Doppler
• Microbubble contrast agent
• Dog
• Tumour
• Radiation therapy

Radiation therapy does not only target tumour cells but also affects tumour vascularity In the present study changes in tumour vascularity and blood volume were investigated in five grade 1 oral fibrosarcomas eight other sarcomas (non-oral soft tissue and bone sarcomas) and 12 squamous cell carcinomas in dogs during fractionated radiation therapy (total dose 45-56 Gy) Contrast-enhanced power Doppler ultrasound was performed before fraction 1 3 6 8 10 12 14 and 15 or 16 (sarcomas) or 17 (squamous cell carcinomas) Prior to treatment median vascularity and blood volume were significantly higher in squamous cell carcinomas (P = 0 0005 and 0 001) whereas measurements did not differ between oral fibrosarcomas and other sarcomas (P = 088 and 0 999) During the course of radiation therapy only small non-significant changes in vascularity and blood volume were observed in all three tumour histology groups (P = 008 and P = 0 213) whereas median tumour volume significantly decreased until the end of treatment (P = 004 for fibrosarcomas and other sarcomas P = 0 008 for squamous cell carcinomas) It appeared that there was a proportional decrease in tumour volume vascularity and blood volume Doppler measurements did not predict progression free interval or survival in a

• 出版日期2010-10