Association of vitiligo and response in patients with metastatic malignant melanoma on temozolomide

作者：Tatli Ali Murat^*; Besen Ali Ayberk; Kalender Mehmet Emin; Uysal Mukremin; Aslan Deniz; Goksu Sema Sezgin; Gunduz Seyda Gulenay; Coskun Hasan Senol

来源：TUMORI JOURNAL, 2015, 101(2): E67-E69.

DOI：10.5301/je.5000253

• Malignant melanoma
• Temozolomide
• Vitiligo-like lesions

Vitiligo-like lesions, although rare, are believed to be a prognostic factor in malignant melanoma. While a predictive role for such lesions was shown with immunomodulatory therapies, this relation was not demonstrated with temozolomide. We present 3 patients with metastatic malignant melanoma who developed vitiligo-like skin lesions accompanying good response to treatment and prolonged survival. Onset of vitiligo-like lesions with temozolomide in metastatic malignant melanoma may predict long-term response for this treatment.

• 出版日期2015-4