Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: Results from a multi-ethnic cohort

作者：Veeranna Vikas; Zalawadiya Sandip K; Niraj Ashutosh; Kumar Abhimanyu; Ference Brian; Afonso Luis^*

来源：International Journal of Cardiology, 2013, 166(2): 487-493.

DOI：10.1016/j.ijcard.2011.11.034

• Inflammation
• Biomarkers
• Cardiovascular disease
• Coronary artery disease
• Ethnicity
• CRP
• Fibrinogen
• Interleukin
• Epidemiology
• Cardiovascular disease
• Risk factors
• Stroke
• Atherosclerosis
• Death
• Outcome

Background: We sought to define the influence of ethnicity on associations between novel biomarkers and cardiovascular disease (CVD) events among Multi-Ethnic Study of Atherosclerosis (MESA) study participants, a community based population of asymptomatic US adults. %26lt;br%26gt;Methods: Baseline (log transformed) levels of biomarkers namely C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), D-dimer, plasmin-antiplasmin complex (PAP) and factor VIII were used to predict the cumulative incidence of all CVD events in an ethnicity stratified study cohort from Cox-proportional hazard analysis where models were adjusted for relevant confounders. %26lt;br%26gt;Results: Ethnic cohorts included 2362 Caucasians, 1601 African Americans, 1353 Hispanics, and 751 Chinese. At mean 4.6 years of follow-up, 286 CVD events were identified with cumulative incidence of 11.3% in Caucasians, 9.8% in African Americans, 11.3% in Hispanics and 6.9% in Chinese. %26lt;br%26gt;Biomarker risk association with CVD events incidence was significantly influenced by ethnicity with positive association (HR, 95% CI, p value) being shown for: CRP among Caucasians only (1.23, 1.04-1.47, %26lt;0.01) IL-6 among African Americans only (1.69, 1.15-2.48, %26lt;0.01) and fibrinogen among Caucasians (3.05, 1.21-7.69, 0.02), African Americans (3.51, 1.09-11.2, 0.03) and Hispanics (4.16, 1.23-14.1, 0.02) only. None of the biomarkers were able to predict CVD in Chinese. Association between above biomarkers and CVD was bidirectional: cases with CVD events had higher mean levels of biomarkers; cases in higher quartiles of biomarkers had increased cumulative incidence of CVD events. %26lt;br%26gt;Conclusion: Study results from a vast, ethnically diverse, asymptomatic US adult population suggest that biomarker association with incident CVD events is significantly influenced by ethnicity.

• 出版日期2013-6-20