Antioxidant status and superoxide anion radical generation in acute myeloid leukemia

作者：Er Tze Kiong; Tsai Shih Meng; Wu Szu Hslen; Chiang Wen; Lin Hsien Cheng; Lin Sheng Fung; Wu Szu Hua; Tsai Li Yu^*; Liu Tsan Zon

来源：Clinical Biochemistry, 2007, 40(13-14): 1015-1019.

DOI：10.1016/j.clinbiochem.2007.05.013

• total antioxidant status
• superoxide anion radical
• malondialdehyde
• acute myeloid leukemia

Objectives: This study was undertaken to investigate if there is a disparity in the antioxidant status and the ability of superoxide anion (O-2(center dot-)) generation in the patients with acute myeloid leukemia (AML).
Design and methods: The peripheral blood samples from thirty AML patients and thirty-six healthy subjects were collected and leukocytes, erythrocytes and plasma were separated for use in various parameter measurements.
Results: The generation Of O-2(center dot-), as reflected by lucigenin-based CL (LBCL), by the leukocytes of patients with AML was found to be significantly elevated either in resting or stimuli-elicited condition as compared with that of healthy controls (p < 0.05). Coincidentally, these data were matched up with the suppressed SOD activities, notably in Cu/Zn SOD isoform found in AML patients (p < 0.05). Conversely, SOD and GPx activities in erythrocytes of patients with AML were shown to be significantly higher than their normal counterparts (p < 0.05).
Conclusions: These data suggest that altered expression of antioxidant enzymes and higher capability Of O-2(center dot-) generation by leukocytes seem to be a distinct feature of AML.

• 出版日期2007-9
• 单位河北医科大学; 长春大学