Application of Sulfonic Acid Functionalized SBA-15 as a New Nanoporous Acid Catalyst in the Green One-Pot Synthesis of Spirooxindole-4H-pyrans

作者：Lashgari Negar; Ziarani Ghodsi Mohammadi^*; Badiei Alireza; Zarezadeh Mehrizi Mansoureh

来源：Journal of Heterocyclic Chemistry, 2014, 51(6): 1628-1633.

DOI：10.1002/jhet.1746

Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a new nanoporous solid acid catalyst was applied in the green one-pot synthesis of spirooxindole-4H-pyrans via condensation of isatins, malononitrile or methyl cyanoacetate or ethyl cyanoacetate, and 4-hydroxycoumarin in water solvent. SBA-Pr-SO3H was proved to be an efficient heterogeneous nanoporous solid acid catalyst with a pore size of 6nm that could be easily handled and removed from the reaction mixture by simple filtration and can be recovered and reused for several times without any loss of activity. The significant merits of present methodology are its simplicity, short reaction time, good yields, and environmentally benign mild reaction condition as water was used as a green solvent.

• 出版日期2014-11