NETosis: At the crossroads of rheumatoid arthritis, lupus, and vasculitis

作者：Berthelot Jean Marie; Le Goff Benoit; Neel Antoine; Maugars Yves; Hamidou Mohamed

来源：Joint Bone Spine, 2017, 84(3): 255-262.

DOI：10.1016/j.jbspin.2016.05.013

• NETosis
• NETs
• Neutrophils
• Polymorphonuclear
• DNA
• PAD4
• Dormant infections
• Rheumatoid arthritis
• Lupus
• Vasculitis

Suicidal NETosis differs from other mechanisms of cell death by the release of a lattice, composed of DNA associated with proteins citrullinated by protein-arginine deiminase 4, from neutrophils. These 'NETs' are-composed of granule-derived proteins with microbicidal activity. A similar type of release occurs duringvital NETosis, in which anuclear neutrophils maintain their chemotactic ability and imprison live bacteria, even after NET extrusion. Mitochondrial NETosis is limited to the expulsion of oxidised mitochondrial DNAand cytoplasmic enzymes. NETs include the targets of most autoantibodies found in rheumatoid arthritis, lupus, and vasculitis. The clinical and biological overlaps sometimes observed between bronchectiasisand RA, RA and SLE, or SLE and vasculitis, implicate NETosis as a major triggering event common tothese disorders. NETosis increases the possibility of association between autoantigens and infectiousantigens in mucosal biofilms, impairing the clearance of pathogens and possibly triggering autoimmunereactions. NETosis aggravates these three conditions and increases endothelial damage and the risk ofthrombosis. However, the pathogenesis of RA, SLE, and vasculitis is not confined to autoantibodies againstNET components, and other mechanisms have been suggested to explain the breakdown of toleranceto NET autoantigens, such as hypercitrullination. The question of whether continuous presentation ofautoantigens mixed with antigens from dormant intracellular pathogens (released following suicidal, vital, or mitochondrial NETosis) is required to induce and sustain autoimmunity must be addressed. Inhibiting NETois may not be sufficient to improve autoimmune disorders whereas such latent infectionsremain uncontrolled.

• 出版日期2017-5