Activation of genes during caudal regeneration of the polychaete annelid

作者：Pfeifer Kathrin; Dorresteijn Adriaan W C; Froebius Andreas C

来源：Development Genes and Evolution, 2012, 222(3): 165-179.

DOI：10.1007/s00427-012-0402-z

• Hox
• Regeneration
• Platynereis
• Gangliosome

The capability of regenerating posterior segments and pygidial structures is ancestral for annelids and has been lost only a few times within this phylum. As one of the three major segmented taxa, annelids enable us to monitor reconstruction of lost tissues and organs. During regeneration, regional identities have to be imprinted onto the newly formed segments. In this study, we show spatial and temporal localization of expression of nine genes during caudal regeneration of the polychaete annelid . genes are homeodomain genes encoding transcriptional regulators of axial patterning in bilaterian animals during development. We demonstrate that five genes belonging to paralog groups (PG) 1, 4, 5, 6, and 9-14 are expressed in domains of the regenerating nervous system consistent with providing positional information along the anteroposterior axis of the regenerate. We report that expression in regenerating neuromeres is limited to varying subsets of perikarya, called gangliosomes. Four of nine genes analyzed do not appear to be involved in axial patterning. Two genes, and , are predominantly expressed in the growth zone region. For some genes expression in newly formed coelomic epithelia can be observed. genes do not exhibit temporal or spatial colinearity. Although there are some similarities to previously reported expression patterns during larval and postlarval development in Nereididae (Kulakova et al. 2007), expression patterns observed during caudal regeneration also show unique patterns.

• 出版日期2012-5