BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint

作者：Swaminathan Srividya; Duy Cihangir; Mueschen Markus

来源：Trends in Immunology, 2014, 35(3): 131-137.

DOI：10.1016/j.it.2013.11.002

• BACH2
• BCL6
• negative selection
• pre-B cell receptor checkpoint
• leukemogenesis

At the pre-B cell receptor (BCR) checkpoint, developing pre-B cells are selected for successful rearrangement of V-H-DJ(H) gene segments and expression of a pre-BCR. Reduced stringency at this checkpoint may obstruct the B cell repertoire with nonfunctional B cell clones. Earlier studies have described that activation of B cell lymphoma/leukemia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the checkpoint. This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint. Here, we discuss the antagonism between BCL6 and BACH2 during early B cell development, as well as its implications in both repertoire selection and counter-selection of premalignant clones for leukemia.suppression.

• 出版日期2014-3