Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins

作者：Gonzalez Trujano Maria Eva; Pellicer Francisco; Mena Pedro^*; Moreno Diego A; Garcia Viguera Cristina

来源：International Journal of Food Sciences and Nutrition, 2015, 66(4): 395-399.

DOI：10.3109/09637486.2015.1024208

• Anti-inflammatory
• antinociception
• anthocyanin
• ellagitannin
• formalin test
• gastroprotection

Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly) phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly) phenolics in the treatment of pain as well as their anti-inflammatory properties.

• 出版日期2015-6