Emergency Use of Intravenous Phytonadione (Vitamin K-1) for Treatment of Severe Bleeding in a Child With Chronic Cholestasis

作者：Glatstein Miguel^*; Idan Prusak Dafna; Yahav Aiala; Ovental Amit; Rimon Ayelet; Scolnik Dennis

来源：American Journal of Therapeutics, 2013, 20(6): E733-E735.

DOI：10.1097/MJT.0b013e318217a5c0

• phytonadione
• vitamin K
• cholestasis
• bleeding

We present a 5-year-old boy with multiple hematomas associated with chronic cholestasis. A week before admission he suffered minor trauma at day care. The next day he complained of trunk and limb pain and orthopedic consultation, including leg x-rays, revealed no abnormalities. Over the next 5 days multiple hematomas developed over his body and increased in size. In the Emergency Department he was in pain and looked sick but alert. He had fever and tachycardia, with normal blood pressure and respiratory status and physical examination showed several hematomas on the legs, which increased in size during observation in the Emergency Department over 2 hours. Blood work revealed multiple coagulation abnormalities, and International Normalized Ratio was 12. Intravenous phytonadione (vitamin K-1) was immediately administered with normalization of coagulation abnormalities within 1 hour and the hematomas stopped growing in size. In addition to missing follow-up with the Pediatric Gastroenterology Department, social service agency inquiry found he had not taken his medications for several months. With severe abnormal bleeding and hepatic disease, intravenous vitamin K-1 may be lifesaving, even before obtaining confirmatory blood work, fresh-frozen plasma, or blood transfusion.

• 出版日期2013-12