A pilot study of depot medroxyprogesterone acetate pharmacokinetics and weight gain in adolescent females

作者：Bonny Andrea E^*; Lange Hannah L H; Rogers Lynette K; Gothard Dave M; Reed Michael D

来源：Contraception, 2014, 89(5): 357-360.

DOI：10.1016/j.contraception.2014.01.017

• Contraception
• Pharmacokinetics
• Adolescence
• Depo Provera
• Weight

Objective: To explore the relationship between medroxyprogesterone acetate (MPA) pharmacokinetic (PK) parameter estimates and weight gain.
Study design: Prospective study of adolescents (N=40; age 12-21 years) initiating DMPA. PK parameters were calculated: maximum MPA concentration (Cmax, ng/mL), time to Cmax (Tmax, days) and elimination rate constant (ng/mL/day). Optimal PK cut points were determined for predicting body mass index (BMI) increase >= 10%.
Results: Cmax <2.88 ng/mL and elimination rate constant <0.021 ng/mL/day were associated (p<.05) with BMI increase 10%. Elimination rate constant was most predictive of weight gain.
Conclusions: PK evaluation may help identify adolescents at risk of excessive DMPA-associated weight gain.

• 出版日期2014-5