Maternal serum activin-A at 30-33 weeks in the prediction of preeclampsia

作者：Lai Jonathan; Pinas Ana; Syngelaki Argyro; Poon Leona C Y; Nicolaides Kypros H^*

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2013, 26(8): 733-737.

DOI：10.3109/14767058.2012.755167

• Activin-A
• preeclampsia
• pyramid of antenatal care
• third trimester screening

Objective: To investigate the potential value of maternal serum concentration of activin-A at 30-33 weeks' gestation in the prediction of preeclampsia (PE) developing at or after 34 weeks.
Methods: Serum concentrations of activin-A were measured at 11-13 and at 30-33 weeks' gestation in a case-control study of 50 cases that developed PE and 250 unaffected controls. The measured values of activin-A were converted into multiples of the unaffected median (MoM), after adjustment for maternal characteristics, and the MoM values in the PE and controls were compared.
Results: The median activin-A MoM at 30-33 weeks was higher in the PE group (1.47, IQR 1.14-2.38 versus 0.99, IQR 0.72-1.42), but at 11-13 weeks there was no significant difference between the groups. In screening by a combination of maternal characteristics and activin-A at 30-33 weeks the detection rate of PE was 50.0%, at a false positive rate of 10%.
Conclusion: Screening by maternal characteristics and activin-A at 30-33 weeks could identify half of the pregnancies that will subsequently develop PE.

• 出版日期2013-5