A Study of the Electrocatalytic Oxidation of Deferiprone and Deferasirox on Nanoshells of NaCo[Fe(CN)(6)]-Applied to Sensing in Pharmaceuticals and Biological Fluids

作者：Sattarahmady N; Heli H^*

来源：Sensor Letters, 2012, 10(3-4): 794-805.

DOI：10.1166/sl.2012.2338

• Deferiprone
• Deferasirox
• Core-Shell Structure
• Cobalt Hexacyanoferrate
• Electrocatalytic Transducer

The electrocatalytic oxidation of deferiprone and deferasirox was studied on a carbon paste electrode modified with nanoparticles of Fe2O3 core-NaCo[Fe(CN)(6)] shell. In the voltammograms, two quasi-reversible redox transitions for Co(II)/Co(III) and Fe(II)/Fe(III) appeared. In the presence of deferiprone, both anodic peak currents increased, followed by decreases in the corresponding cathodic currents. In the presence of deferasirox, however, only the peak current located at higher potentials increased followed by a decrease in the corresponding cathodic current. Based on the results, the drugs were oxidized on nanoshells of NaCo[Fe(CN)(6)] nanoparticles via electrocatalytic mechanisms. The catalytic rate constants, the electron transfer coefficients and the diffusion coefficients involved in the electrooxidation of the drugs were reported. A sensitive and efficient amperometric procedure was presented for the analysis of the drugs in both bath and flow systems. For deferiprone, detection limits of 2.14 mu M and 59.16 nM in batch and flow systems were obtained, respectively. For deferasirox, detection limits of 0.91 mu M and 53.4 nM were obtained in batch and flow systems, respectively. The proposed amperometric method was also applied to the analysis of commercial tablets and the direct assays of the drug metabolites in human serum and urine.

• 出版日期2012-4