Morphology and electrostatics play active role in neuronal differentiation processes on flexible conducting substrates

作者：Srivastava Nishit; James Jackson; Narayan K S^*

来源：Organogenesis, 2014, 10(1): 1-5.

DOI：10.4161/org.27213

• electrostatics
• cell differentiation
• neuronal cells
• stretched substrates
• conducting polymers

This commentary discusses and summarizes the key highlights of our recently reported work entitled %26quot;Neuronal Differentiation of Embryonic Stem Cell Derived Neuronal Progenitors Can Be Regulated by Stretchable Conducting Polymers.%26quot; The prospect of controlling the mechanical-rigidity and the surface conductance properties offers a unique combination for tailoring the growth and differentiation of neuronal cells. We emphasize the utility of transparent elastomeric substrates with coatings of electrically conducting polymer to realize the desired substrate-characteristics for cellular development processes. Our study showed that neuronal differentiation from ES cells is highly influenced by the specific substrates on which they are growing. Thus, our results provide a better strategy for regulated neuronal differentiation by using such functional conducting surfaces.

• 出版日期2014-1-1