Down regulation of miR-143 promotes radiation - Induced thymic lymphoma by targeting B7H1

作者：Zhao Hainan; Cheng Ying; Dong Suhe; Du Jicong; Gao Fu; Sun Ding; Cui Jianguo; Ni Jin; Cai Jianming

来源：Toxicology Letters, 2017, 280: 116-124.

DOI：10.1016/j.toxlet.2017.07.891

• Radiation carcinogenesis
• Radiation induced thymic lymphoma (RITL)
• miR-143
• B7H1
• Tumor therapy

MicroRNA-143 has been implicated in tumor metastasis by directly targeting Bcl-2, and microRNA-143 expression is decreased in several human tumors. However, the expression and targets of miR-143 in radiation carcinogenesis remain unclear. We found that the expression of miR-143 is down-regulated and the expression of B7H1 (Pdcd1) is up-regulated in radiation-induced thymic lymphoma model in BALB/c mice. Additionally, overexpression of miR-143 strongly inhibited cell proliferation and increased cell apoptosis and its down-regulation promoted cell proliferation and reduced cell apoptosis. We also determined that there is an inverse correlation between miR-143 expression and B7H1 protein expression in radiation-induced thymic lymphoma samples, and miR-143 targets B7H1 in a 3'UTR-dependent manner. In addition, we found that adenovirus overexpression of pre-miR-143 reduced tumorigenesis in vivo. Finally, we conclude that down-regulated expression of miR-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR-143 or inhibition of B7H1.

• 出版日期2017-10-5
• 单位中国人民解放军第二军医大学