Ablative zone size created by radiofrequency ablation with and without chemoembolization in small hepatocellular carcinomas

作者：Yamanaka Takashi^*; Yamakado Koichiro; Takaki Haruyuki; Nakatsuka Atsuhiro; Shiraki Katsuya; Hasegawa Hiroshi; Takei Yoshiyuki; Takeda Kan

来源：Japanese Journal of Radiology, 2012, 30(7): 553-559.

DOI：10.1007/s11604-012-0087-2

• Abdomen
• Ablation procedure
• Chemoembolization
• Liver cirrhosis

We retrospectively evaluated whether combined use of chemoembolization expands ablative zone sizes created by radiofrequency (RF) ablation in patients with small hepatocellular carcinomas (HCCs). %26lt;br%26gt;Fifty-seven patients treated with single RF ablation for solitary HCC measuring a parts per thousand currency sign2 cm were assessed. RF ablation alone was done in nine patients and in 48 patients following chemoembolization, with an interval of 0 days in 6, 1-14 days in 27, 15-28 days in 6, and a parts per thousand yen4 weeks in 9. Ablative zone sizes, disappearance of tumor enhancement, and creation of sufficient ablative margins (%26gt; 5 mm) were evaluated on contrast-enhanced computed tomography (CT) images. %26lt;br%26gt;Both mean long-axis (4.2-4.7 vs. 3.6 +/- A 0.4 cm, p %26lt; 0.04) and short-axis (3.3-3.8 vs. 2.3 +/- A 0.5 cm, p %26lt; 0.03) diameters were expanded significantly when RF ablation was done until 4 weeks after chemoembolization than with RF ablation alone. Tumor enhancement disappeared in all patients. Frequency of achieving sufficient ablative margins was significantly higher when RF ablation was done until 4 weeks after chemoembolization than with RF ablation alone (74.0-83.3 vs. 22.2 %, p %26lt; 0.05). %26lt;br%26gt;Ablative zones created by RF ablation with chemoembolization become larger than RF ablation alone, leading to secure ablative margins.

• 出版日期2012-8