Angiotensin AT(1) Receptors and Their Ligands (Review)

作者：Spasov A A; Yakovlev D S^*; Brigadirova A A

来源：Pharmaceutical Chemistry Journal, 2017, 51(1): 1-8.

DOI：10.1007/s11094-017-1546-y

• AT(1) receptor
• AT(1) antagonists
• angiotensin
• sartans
• arterial hypertension
• renin-angiotensin system
• vasoconstriction

This review addresses on the most intensely studied biological targets in the body - type 1 angiotensin receptors. Particular attention is focused on receptor structure and its interaction with various intracellular signal molecules. Data on long-known and newly created ligands able to influence AT(1) receptors are presented. The individual structural fragments of AT(1) antagonist molecules with functional significance for this type of activity are described. The review includes a brief analysis of the potentials for the clinical use of AT(1) antagonists in a number of pathological states additional to the registered indications, including arterial hypertension, chronic heart failure, and nephropathy in type 2 diabetes mellitus. These results from the discovery of additional aspects of the mechanism of action of antagonists and their ability to produce effects such as neuroprotective and anti-inflammatory actions, as well as various organ-protective properties.

• 出版日期2017-4