Abnormal expressions of inflammatory-related mediators and inhibition of fat metabolism in mice infected with influenza a virus

作者：Yao, Min; Wang, Li; Yao, Dengbing; Yao, Dengfu^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2015, 28(3): 1109-1114.

• Virus infection
• fat metabolism
• cytokines
• camitine and mice

The pathophysiological role of influenza infection is poorly understood. In this study, one non-neurovirulent virus (IAV/Aichi/2/68/H3N2) strain was used to infect intra-nasally mice at different age to investigate the mechanism of cerebral edema formation and lower activities of mitochondria enzymes after influenza A virus (JAY) infection. Mice suffered 46.4% mortality in newborn compared with 96.0% in weanling, 100% in adult on day 7, respectively. IAV-RNA was easily detected in the brain of newborn mice. Significant production of endothelin-1 and inducible nitric oxide syntheses were increased on the 3rd and 5th day after IAV infection, associated with increasing blood-brain barrier permeability, brain edema formation and the higher mortality of animals. Production of tumor necrosis factor-alpha was related to inhibition of mitochondrial enzyme activities, suggesting that over expression of inflammatory cytokines and lower enzyme activities in mitochondria after IAV infection.

• 出版日期2015-5
• 单位南通大学