Urease inhibition of oxovanadium(V) complexes with hydrazone and hydroxamate ligands

作者：Sheng, G. H.^*; Huo, Y.; Ye, Y. T.; You, Z.; Zhu, H. L.

来源：Russian Journal of Coordination Chemistry, 2014, 40(9): 664-670.

DOI：10.1134/S1070328414090085

• HELICOBACTER-PYLORI UREASE
• SCHIFF-BASES
• BIOLOGICAL-ACTIVITY
• MOLECULAR DOCKING
• METAL-COMPLEXES
• DERIVATIVES
• CHEMISTRY
• ACIDS
• DNA

Two new oxovanadium(V) complexes, [VOL1(SHA)] (I) and [VOL2(BHA)] (II), were prepared by the reaction of [VO(Acac)(2)] (Acac = acetylacetonate) with N'-(2-hydroxybenzylidene)isonicotinohydrazide (H2L1) and salicylhydroxamic acid (HSHA) and 4-chloro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide (H2L2) and benzohydroxamic acid (HBHA), respectively, in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectra and single crystal X-ray diffraction (CIF file CCDC nos. 978238 (I) and 978392 (II)). The V atoms are in octahedral coordination. Thermal stability and the inhibition of urease of the complexes were studied.

• 出版日期2014-9
• 单位山东理工大学; 辽宁师范大学