Acetyl-L-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells

作者：Zhang Zhaofeng; Zhao Ming; Li Qiong; Zhao Haifeng; Wang Junbo^*; Li Yong

来源：FEBS Letters, 2009, 583(2): 470-474.

DOI：10.1016/j.febslet.2008.12.053

• Acetyl-L-carnitine
• AMP-activated protein kinase
• Insulin resistance
• Tumor necrosis factor-alpha

In this study, we demonstrated effects of acetyl-L-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in rat L6 cells. TNF-alpha downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-alpha-induced insulin resistance through AMPK pathway in skeletal muscle cells.

• 出版日期2009-1-22
• 单位北京大学