A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques

作者：Lim SinChun; Paterson Brett M; Fodero Tavoletti Michelle T; O'Keefe Graeme J; Cappai Roberto; Barnham Kevin J; Villemagne Victor L^*; Donnelly Paul S

来源：Chemical communications, 2010, 46(30): 5437-5439.

DOI：10.1039/c0cc01175d

A bis(thiosemicarbazonato)copper(II) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

• 出版日期2010