Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population

作者：Koh Eun Sil; Kim Sung Jun; Yoon Hye Eun; Chung Jong Hee; Chung Sungjin; Park Cheol Whee; Chang Yoon Sik; Shin Seok Joon^*

来源：BMC Endocrine Disorders, 2014, 14(1): 24.

DOI：10.1186/1472-6823-14-24

• Manganese
• Diabetes
• Renal dysfunction

Background: The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population. %26lt;br%26gt;Methods: This was a cross-sectional study based on the Korean National Health and Nutrition Examination Survey (KNAHNES). The study included 3996 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke. %26lt;br%26gt;Results: Blood manganese levels were significantly lower in the diabetes group compared with the non-diabetes group (1.26 +/- 0.02 vs. 1.35 +/- 0.01 mu g/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal 1.28 +/- 0.03 vs. 1.35 +/- 0.01 mu g/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46-0.92) for diabetes and 0.589 (95% CI: 0.39-0.88) for renal dysfunction when comparing the higher quartiles (Q2-4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2-4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2-4 (p = 0.02). %26lt;br%26gt;Conclusion: The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.

• 出版日期2014-3-8