A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke-Blackburn-Bienayme reaction under catalyst-free and solvent-free conditions

作者：Vidyacharan Shinde^*; Shinde Anand H; Satpathi Bishnupada; Sharada Duddu S

来源：Green Chemistry, 2014, 16(3): 1168-1175.

DOI：10.1039/c3gc42130a

A one-pot catalyst, solvent, work-up and column free synthesis of 3-aminoimidazo-fused heterocycles by a three-component reaction of a 2-aminoheterocycle, aldehyde, and isocyanide is presented. This efficient and green protocol has the advantages of environmental friendliness, high yields and operational simplicity.

• 出版日期2014