N-terminal pro-brain natriuretic peptide can be an adjunctive diagnostic marker of hyper-acute phase of Kawasaki disease

作者：Kwon Hyuksool; Lee Jin Hee; Jung Jae Yun; Kwak Young Ho^*; Kim Do Kyun; Jung Jin Hee; Chang Ikwan; Kim Kyuseok

来源：European Journal of Pediatrics, 2016, 175(12): 1997-2003.

DOI：10.1007/s00431-016-2798-3

• Diagnostic marker
• Fever
• Kawasaki disease
• N-terminal pro-brain natriuretic peptide

The purpose of this study was to determine whether the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level could be a useful marker for Kawasaki disease in the pediatric emergency department (PED) and in the presence of fever duration of 4 days or less (hyper-acute phase of Kawasaki disease). Medical records of patients who were 1 month to 15 years old of age and presented at the PED with suspected Kawasaki disease from January 1, 2010, to December 31, 2014, were collected retrospectively. Two hundred thirty-nine patients with a history of fever for 4 days or less were diagnosed with Kawasaki disease, as well as 111 patients with other febrile diseases, and were enrolled. The NT-proBNP level was significantly higher in patients with Kawasaki disease (Kawasaki disease vs. other febrile disease group, 444.8 (189.7-951.5) vs. 153.4 (68.9-287.6) pg/mL; p < 0.001), and a cutoff value of 244.7 pg/mL yielded a sensitivity and specificity of 68.6 and 70.3 %, respectively. The area under the curve of the NT-proBNP for predicting Kawasaki disease was 0.763 (95 % CI 0.712-0.814).
Conclusion: NT-proBNP might be an adjunctive laboratory marker for hyper-acute phase of Kawasaki disease in the PED.

• 出版日期2016-12