Comparative Activities of the S-Enantiomer and Racemic Forms of Equol on Bone Fragility in Ovariectomized Mice

作者：Kimira Yoshifumi; Katsumata Shin ichi; Suzuki Kazuharu; Ishimi Yoshiko; Ueno Tomomi; Uchiyama Shigeto; Adlercreutz Herman; Uehara Mariko^*

来源：Bioscience Biotechnology and Biochemistry, 2012, 76(5): 1018-1021.

DOI：10.1271/bbb.110973

• soy isoflavones
• S(-)-equol
• racemic(+/-)-equol
• osteoporosis
• ovariectomized mice

We compared the effects of the S-enantiomer and racemic forms of equol on bone using ovariectomized (OVX) mice. Femoral bone mineral density and bone strength decreased in the OVX mice, but not in OVX mice administered 0.5 mg/d S-equol. This, however, did not hold for racemic equol. Serum and urine S-equol concentrations were higher in the mice administered S-equol than in those administered racemic equol. These results suggest that the inhibitory effects of S-equol on bone fragility in OVX mice are greater than those of racemic equol.

• 出版日期2012-5