Secondary metabolites of Sophora mollis subsp griffithii (Stocks) Ali

作者：Atta ur Rahman; Haroone M Sohail; Tareen Rasool Baksh; Mesaik M Ahmed; Jan Saleem; Abbaskhan Ahmed; Asif Muhammad; Gulzar Tahsin; Al Majid Abdullah M; Yousuf Sammer; Choudhary M Iqbal^*

来源：Phytochemistry Letters, 2012, 5(3): 613-616.

DOI：10.1016/j.phytol.2012.06.006

• Sophora mollis
• Leguminoseae
• Sophoranone
• CD Spectrum
• Immunomodulatory activity

Two new compounds, (+)-3,5,7-trihydroxy-3-[3%26apos;-hydroxy-2%26apos;,4%26apos;-dimethoxy-5-(3-methyl-2-butenyl)]phenyl-(3R)-4H-1-benzopyran-4-one (1) and (-)-3-hydroxy-8,9-methylenedioxy-(6aR,11aS)-pterocarpan (2), were isolated from the methanolic extract of Sophora mollis subsp. griffithii. Two known compounds, beta-sitosterol (3) and 19 beta H-lupeol-methyl-ether (4), were also obtained for the first time from this plant. The structures of 1-4 were identified through their spectroscopic data. CD Spectroscopy was also utilized for the structure elucidation of compounds 1 and 2. Compounds 1, 3 and 4 were studied for their effects on immune cells and only 1 was found to be substantially active.

• 出版日期2012-9