A novel dextran-oleate-cRGDfK conjugate for self-assembly of nanodrug

作者：Wang Zhe; Lee Ting Yee; Ho Paul C^*

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2012, 8(2): 194-203.

DOI：10.1016/j.nano.2011.06.006

• Dextran
• Poly(ethylene glycol)
• Nanoparticle
• Paclitaxel
• Cyclic (Arg-Gly-Asp-D-Phe-Lys) (cRGDfk)

We report a novel synthetic biocompatible material: a conjugate with a fatty acid-substituted dextran decorated with cRGDfK peptide, which was used as a stable coating material instead of the conventional poly(ethylene glycol) for nanodrug preparation. This novel dextran-oleate-cRGDfK conjugate (DO-cRGDfk) could self-assemble into a micellar structure in aqueous solution, and was used as a surfactant to formulate nanodrug with poly(d,l-lactic-co-glycolic) acid as matrix to encapsulate paclitaxel with high drug-loading efficiency. The conjugate allowed the fabrication of nanodrug with a targeting moiety on its surface in a simple and robust step. The resultant nanoparticles could induce cellular apoptosis more effectively than that of the commercial paclitaxel formulation, Taxol. Thus, DO-cRGDfk could be used as an alternative to poly(ethylene glycol) as a biocompatible surface coating polymeric material for nanoparticle preparation.
From the Clinical Editor: The authors describe a novel synthetic biocompatible conjugate, which consists of a fatty acid-substituted dextran decorated with cRGDfK peptide. This conjugate was used as a stable coating material for nanodrug preparation, and can be used in place of conventional PEG.

• 出版日期2012-2