Development of beta-hydroxyamide/titanium complexes for catalytic enantioselective silylcyanation of aldehydes

作者：Uang BJ^*; Fu IP; Hwang CD; Chang CW; Yang CT; Hwang DR

来源：Tetrahedron, 2004, 60(46): 10479-10486.

DOI：10.1016/j.tet.2004.08.083

• cyanohydrin
• asymmetric catalysis
• titanium complex
• beta-hydroxyamide

A highly enantioselective addition of trimethylsilylcyanide to aldehydes catalyzed by chiral titanium complexes is described. The chiral titanium complexes were prepared in situ from Ti((OPr)-Pr-i)(4) and beta-hydroxyamide ligands, that could easily be synthesized from ketopinic acid and C-2 symmetrical chiral diamines in a small number of steps.

• 出版日期2004-11-8
• 单位清华大学