ATG5 expression induced by MDMA (ecstasy), interferes with neuronal differentiation of neuroblastoma cells

作者：Chae Myounghee; Rhee Gyu Seek; Jang Ik Soon; Kim Kwangsoo; Lee Ji Hae; Lee Seung Yeul; Kim Minjung; Yang Junyoung; Park Junsoo^*; Lee Seung Hoon

来源：Molecules and Cells, 2009, 27(5): 571-575.

DOI：10.1007/s10059-009-0075-2

• Atg5
• autophagy
• MDMA
• neuron
• PC12
• SH-SY5Y

The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

• 出版日期2009-5