Diselenide- and Disulfide-Mediated Synthesis of Isocoumarins

作者：Shahzad Sohail A; Venin Claire; Wirth Thomas^*

来源：European Journal of Organic Chemistry, 2010, (18): 3465-3472.

DOI：10.1002/ejoc.201000308

• Homogeneous catalysis
• Cyclization
• Diselenides
• Isocoumarins

Cyclizations of stilbenecarboxylic acids to the corresponding isocoumarin derivatives using diselenide or disulfide reagents have been developed. By employing bis(triflouroacetoxy)iodobenzene as oxidant for the 6-endo-trig cyclizations a variety of dihydroisocoumarins have been prepared in good yields. This method is capable of forming isocoumarins and dihydroisocoumarin derivatives by a cyclization-elimination route.

• 出版日期2010-6