Application of Functionalized N,S-Ketene Acetals-Microwave-Assisted Three-Component Domino Reaction for Rapid Direct Access to Imidazo[1,2-a]pyridines

作者：Li, Ming^*; Li, Tengfei; Zhao, Kelong; Wang, Mingda; Wen, Lirong

来源：Chinese Journal of Chemistry, 2013, 31(8): 1033-1038.

DOI：10.1002/cjoc.201300252

• imidazo[1
• 2-a]pyridines
• N
• S-ketene acetals
• multicomponent reaction
• domino reaction
• microwave irradiation

Imidazo[1,2-a]pyridines have been successfully synthesized in moderate to good yields via a tandem three-component reaction of ethyl 2-(3-oxo-3-arylpropanethioamido)acetates with aromatic aldehydes and malononitrile by means of microwave irradiation using DABCO as the catalyst. The advantages of this method including high chemo- and regioselectivity make this new strategy highly attractive.

• 出版日期2013-8
• 单位青岛科技大学