First synthesis of 22-oxa-chenodeoxycholic acid analogue

作者：Wang, Yaoling; Yue, Qiming; Zhao, Yi; Qiu, Shubing; Peng, Yao; Li, Jue; Zhang, Tao; Hai, Li; Guo, Li^*; Wu, Yong^*

来源：Steroids, 2016, 110: 70-76.

DOI：10.1016/j.steroids.2016.04.004

• Chenodeoxycholic acid
• Analogue
• Oxa
• Synthesis

In this study, we report the first synthesis of 22-oxa-chenodeoxycholic acid analogue via androstenedione and progesterone, in 11 and 8 steps with overall yields of 6.4% and 12.7%, respectively. We anticipate this will help to facilitate the development of new drugs.

• 出版日期2016-6
• 单位中国人民解放军成都军区总医院; 四川大学