A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection

作者：Ssentongo Paddy; Robuccio Anna E; Thuku Godfrey; Sim Derek G; Nabi Ali; Bahari Fatemeh; Shanmugasundaram Balaji; Billard Myles W; Geronimo Andrew; Short Kurt W; Drew Patrick J; Baccon Jennifer; Weinstein Steven L; Gilliam Frank G; Stoute Jose A; Chinchilli Vernon M; Read Andrew F; Gluckman Bruce J; Schiff Steven J^*

来源：Scientific Reports, 2017, 7(1): 43652.

DOI：10.1038/srep43652

One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP.

• 出版日期2017-3-8