An easy synthetic approach to 1,2,3-triazole-fused heterocycles

作者：Fiandanese Vito^*; Marchese Giuseppe; Punzi Angela; Iannone Francesco; Rafaschieri Giacomo G

来源：Tetrahedron, 2010, 66(46): 8846-8853.

DOI：10.1016/j.tet.2010.09.068

• Cycloaddition
• Click chemistry
• Alkynes
• Azides
• Triazole-fused heterocycles

A convenient synthesis of 1,2,3-triazole-fused isoindolines and dihydroisoquinolines in good to excellent yield is reported, starting from easily available terminal alkynes and (2-haloaryl)alkylazides. The method is based upon a cycloaddition reaction, via click chemistry, followed by a transition metal-catalyzed functionalization of a C-H bond.

• 出版日期2010-11-13