A single-dose, open-label, parallel, randomized, dose-proportionality study of paliperidone after intramuscular injections of paliperidone palmitate in the deltoid or gluteal muscle in patients with schizophrenia

作者：Cleton Adriaan; Rossenu Stefaan; Crauwels Herta; Berwaerts Joris; Hough David; Gopal Srihari; Eerdekens Marielle; Vandebosch An; Remmerie Bart^*; De Meulder Marc; Rosso Clara M

来源：JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 54(9): 1048-1057.

DOI：10.1002/jcph.295

• dose-proportionality
• long-acting injectable
• paliperidone palmitate
• schizophrenia

Paliperidone palmitate (PP) is a long-acting injectable (LAI) antipsychotic, developed for monthly intramuscular (i.m.) administration into deltoid/gluteal muscle, approved for the treatment of schizophrenia in many countries. To assess the options for i.m. injection sites, dose-proportionality of PP was investigated after injection of a single dose (25-150mgeq.) of PP in either gluteal (n=106) or deltoid (n=95) muscle of schizophrenic patients. Overall, mean (geometric) area under plasma concentration-time curve from time zero to infinity (AUC) of paliperidone increased proportionally with increasing PP doses, regardless of injection site. Mean maximum plasma concentration (Cmax) was slightly less than dose-proportional for both injection sites at PP doses >50mgeq. Mean Cmax was higher after injection in the deltoid compared with the gluteal muscle, except for the 100mgeq. dose, while AUC for both injection sites was comparable at all doses. Median time to reach Cmax (tmax) ranged from 13-14 days after deltoid and 13-17 days after gluteal injection across all doses. Single PP injections in deltoid and gluteal muscles in the dose range of 25-150mgeq. were generally tolerable both locally and systemically.

• 出版日期2014-9