A follow-up study of Nordic multiple sclerosis candidate gene regions

作者：Datta P; Harbo H F^*; Ryder L P; Akesson E; Benedikz J; Celius E G; Andersen O; Myhe K M; Sandberg Wollheim M; Hillert J; Svejgaard A; Sorensen P S; Spurkland A; Oturai A

来源：Multiple Sclerosis, 2007, 13(5): 584-589.

DOI：10.1177/1352458506071790

• candidate regions
• GAMES
• genetics
• HLA
• LID screens
• multiple sclerosis
• Nordic countries

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), DIS2627 (1p22), D6S273 (6p21.33, HLA class III) and D72S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population.

• 出版日期2007-6