MTP-493G/T gene polymorphism is associated with steatosis in hepatitis C-infected patients

作者：Siqueira E R F; Oliveira C P M S^*; Correa Giannella M L; Stefano J T; Cavaleiro A M; Fortes M A H Z; Muniz M T C; Silva F S; Pereira L M M B; Carrilho F J

来源：Brazilian Journal of Medical and Biological Research, 2012, 45(1): 72-77.

DOI：10.1590/S0100-879X2011007500160

• Hepatitis C
• Steatosis
• Fibrosis
• Microsomal transfer protein

The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson's disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the patients with fibrosis grade 3+4 presented at least one G allele versus 34.3% of the patients with fibrosis grade 1+2 (OR = 1.8; 95%CI = 1.3-2.3). Logistic regression analysis with steatosis as the dependent variable identified genotypes GG+GT as independent protective factors against steatosis (OR = 0.4, 95%CI = 0.2-0.8; P = 0.01). The results suggest that the presence of the G allele of MTP -493G/T associated with lower hepatic MTP expression protects against steatosis in our CHC patients.

• 出版日期2012-1