Antibacterial, cytotoxic and phytochemical screening of some traditional medicinal plants in Brazil

作者：Bouzada Maria L M; Fabri Rodrigo L; Nogueira Mauro; Konno Tatiana U P; Duarte Gizele G; Scio Elita^*

来源：Pharmaceutical Biology, 2009, 47(1): 44-52.

DOI：10.1080/13880200802411771

• Antibacterial
• Artemia salina
• cytotoxicity
• medicinal plants

As part of a program oriented towards the discovery of bioactive natural products, 44 methanol extracts from 37 Brazilian traditional medicinal plants, most of them commonly used for treating conditions likely to be associated with microorganisms, were evaluated for their antibacterial activity and toxicity to brine shrimp. The agar-well diffusion method was used against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Shigella sonnei, Klebsiella pneumoniae, Escherichia coli, and Bacillus cereus. The active extracts were subjected to serial dilution assay for determination of the minimal inhibitory concentration. Phytochemical analysis of the extracts for their major groups of phytoconstituents is also reported. Extracts of Baccharis dracunculifolia, Cajanus cajan, Eugenia uniflora, Solanum palinacanthum and Solanum concinnum presented strong antibacterial activity with MIC values below 10 mu g/mL for some bacterial strains. The extracts of Mikania glomerata and Leonurus sibiricus showed significant toxicity against brine shrimp with LC(50) values of 63 and 86 mu g/mL, respectively.

• 出版日期2009-1